What is LGSOC?
Low-grade serous ovarian cancer (LGSOC) is a subtype of ovarian cancer that is characterized by younger age at diagnosis and resistance to chemotherapy. It occurs in the epithelial cells that line the surface of the ovary.
Represents 6-8% of all ovarian cancers.1
Typically diagnosed in women 45-55 years of age.1
Associated with slow tumor growth.1
- Associated with variations in mutations in the BRAF and RAS genes.2
Mutations in the KRAS gene (KRAS+) are present in 35-57% of LGSOC cases.1
85% of patients who achieve full remission following first-line therapy will develop recurrent disease.3
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1 Grisham, R. Low grade serous carcinoma of the ovary. Oncology. 2016. 30(7):650-652. Available at: https://www.cancernetwork.com/view/low-grade-serous-carcinoma-ovary. Accessed December 3, 2020.
2 National Organization for Rare Disorders. Ovarian Cancer. Available at: https://rarediseases.org/rare-diseases/ovarian-cancer/. Accessed December 3, 2020.
3 Corrado G, Salutari V, Palluzzi E, Distefano MG, Scambia G, Ferrandina G. Optimizing treatment in recurrent epithelial ovarian cancer. Expert Rev Anticancer Ther. 2017;17:1147-1158. doi: 10.1080/14737140.2017.1398088.
4 American Cancer Society. Signs and Symptoms of Ovarian Cancer. Available at:
https://www.cancer.org/cancer/ovarian-cancer/detection-diagnosis-staging/signs-and-symptoms.html. Accessed December 3, 2020.
5 Slomovitz, Gourley, Carey, Malpica, Shih, Huntsman, Fader., Grisham et al, Low-Grade serous ovarian cancer: State of the Science; Gynecol Oncol; 2020.